Christophe J. Chipot

The paper compares aromatic ring flip kinetics in GB1 protein across crystals, IgG complexes, and solution, showing reduced flipping in crystals and revealing how crystal environments restrain motion.

This study shows dimeric Alix nucleates CHMP4 polymerization, essential for ESCRT-III membrane remodeling, and demonstrates that dimerization is required for plasma membrane repair.

The paper elucidates the structural basis of the two-photon photoactivation mechanism of orange carotenoid protein using a combination of structural and biochemical methods.

This study investigates how vortioxetine interacts with human and rodent 5-HT3 receptors, revealing structural differences and mechanisms of action.

The paper reports the cryo-EM structure of the palonosetron-bound 5-HT3 receptor and investigates binding modes of antiemetic drugs using molecular dynamics.

The paper uses molecular dynamics simulations to study HBV capsid assembly modulators, identifying structures that predict assembly outcomes and discovering compounds with anti-viral activity.