Guy Schoehn

Thylakoid plasticity primes photoprotection in diatoms

This study identifies three photoprotective mechanisms in diatoms under light stress: detachment of oxygen-evolving complex proteins, NPQ in the antenna, and energy spillover between photosystems.

Assembly of the essential SpoIVA coat protein at the surface of developing bacterial spores

This study reveals that SpoIVA forms track-like polymers during bacterial spore development, with dimerization and ATPase activity playing distinct roles in its assembly and function.

The immunosuppressant tacrolimus (FK506) inhibits C. glabrata Cdr1 efflux pump function by stabilizing the inward-facing conformation.

This paper reveals that tacrolimus inhibits C. glabrata Cdr1 by stabilizing its inward-facing conformation, blocking ATP hydrolysis and azole transport.

ULTRAPETALA1 remodels PRC2 recruitment to nucleosomes

The paper identifies a plant-specific PRC2 variant, PRC2.3, which uses ULTRAPETALA1 to target nucleosomes and deposit H3K27me3 at developmental genes.

Cryo-EM of ATP-driven dynamics and itraconazole binding of the fungal drug efflux ABC pump Candida glabrata Cdr1

The paper presents cryo-EM structures of the fungal ABC pump Cdr1, revealing its ATP-driven dynamics and drug-binding mechanism.

R6G narrows BmrA conformational spectrum for a more efficient use of ATP

This study shows that Rhodamine6G binding to BmrA narrows its conformational spectrum, enhancing ATP-dependent transport efficiency.

Structures of vesicular stomatitis virus glycoprotein G alone and in complex with a neutralizing antibody

This study reports cryo-EM structures of vesicular stomatitis virus glycoprotein G alone and in complex with a neutralizing antibody, revealing conformational changes and epitope details.

Structural Determinants for Activity of the Antidepressant Vortioxetine at Human and Rodent 5-HT3 receptors

This study investigates how vortioxetine interacts with human and rodent 5-HT3 receptors, revealing structural differences and mechanisms of action.

Structure of the human heparan sulfate polymerase complex EXT1-EXT2

The paper presents the cryo-EM structure of the human EXT1-EXT2 complex, revealing its dimeric architecture and catalytic specificity in heparan sulfate biosynthesis.

The binding of palonosetron and other antiemetic drugs to the serotonin 5-HT3 receptor

The paper reports the cryo-EM structure of the palonosetron-bound 5-HT3 receptor and investigates binding modes of antiemetic drugs using molecular dynamics.