Inhibition of the EBF1-ITGB8 Axis in Bone Marrow Niche Ameliorates Hallmarks of Myelofibrosis
Lyudmila G. Tsurkan, Mélodie Douté, Nicholas Morchel, Lahiri Konada, Rashid Mehmood, Te Ling, Amha Atakilit, Bridget Kelly Marcellino, Ronald Hoffman, Peter Vogel, Dean Sheppard, John D. Crispino, Marta Derecka
This study identifies EBF1 and ITGB8 as key regulators of BM fibrosis in myelofibrosis and shows their inhibition reduces disease features in mouse models.
bioRxiv · Feb 17, 2026 · PreprintCell Biology