Peter Vogel

Mitochondrial Integrated Stress Response Activation Creates a Therapeutic Vulnerability to MCL-1 Inhibition in Acute Myeloid Leukemia

This study identifies co-targeting of MCL-1 and ETC complex I as a synergistic therapy for high-risk AML, showing improved viability reduction and survival in preclinical models.

Inhibition of the EBF1-ITGB8 Axis in Bone Marrow Niche Ameliorates Hallmarks of Myelofibrosis

This study identifies EBF1 and ITGB8 as key regulators of BM fibrosis in myelofibrosis and shows their inhibition reduces disease features in mouse models.

The critical role of the ZBP1-NINJ1 axis and IRF1/IRF9 in ethanol-induced cell death, PANoptosis, and alcohol-associated liver disease

Somatic mtDNA Mutation Burden Shapes Metabolic Plasticity in Leukemogenesis

This study shows that somatic mtDNA mutations affect metabolic plasticity in leukemia development, with heterozygous mutations supporting NMyc-driven leukemia while homozygous mutations impair it.

Ixodes ricinus bites promote allergic skin inflammation and intestinal tuft and mast cell expansion in mice.

This study shows that Ixodes ricinus bites in mice cause skin inflammation and intestinal changes similar to allergic reactions and red meat allergy predisposition.

Dynamically Linking Influenza Virus Infection Kinetics, Lung Injury, Inflammation, and Disease Severity

This study links influenza virus infection kinetics to lung injury, inflammation, and disease severity using a model-experiment framework.

Requirement for Anti-Apoptotic MCL-1 during Early Erythropoiesis

This study shows that MCL-1 is essential for the survival of early erythroid progenitors, while BCL-xL takes over in later stages of erythropoiesis.