Author

Lance C. Novak

The University of Texas MD Anderson Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Christopher Aaron BristowiD· 2 shared Traver HartiD· 2 shared Eiru KimiD· 1 shared Juihsuan Chou· 1 shared Medina ColiciD· 1 shared Veronica GheorgheiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersBioinformatics

Christopher Aaron BristowORCID

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2 papers

Recent·Most cited

PICKLES v3: the updated database of pooled in vitro CRISPR knockout library essentiality screens

Lance C. Novak, Juihsuan Chou, Medina Colic, Christopher Aaron Bristow, Traver Hart

PICKLES v3 provides an updated database of CRISPR knockout screens in human cell lines, enabling exploration of gene fitness across multiple libraries and cell lines.

Nucleic Acids Research · Nov 3, 2022Peer-reviewedBioinformatics

Dynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions

Eiru Kim, Lance C. Novak, Veronica Gheorghe, Christopher Aaron Bristow, Traver Hart

The paper identifies context-dependent functional interactions from CRISPR screens, revealing how genotype and lineage influence gene coessentiality and pathway rewiring.

bioRxiv · Jun 25, 2021 · PreprintSystems Biology