Eiru Kim

This study identifies ROCK inhibition as a strategy to overcome metabolic adaptation in cancer cells to OXPHOS inhibition, showing synergistic anti-tumor effects.

The paper identifies context-dependent functional interactions from CRISPR screens, revealing how genotype and lineage influence gene coessentiality and pathway rewiring.

The paper introduces BAGEL2, an improved CRISPR fitness screen analysis tool that reduces off-target effects and enhances detection of tumor suppressor genes.

The paper shows that paralog buffering limits detection of synthetic lethal interactions in CRISPR screens, revealing many under-detected genetic dependencies.

The paper identifies novel tumor suppressors from CRISPR screens and reveals rewired lipid metabolism in AML cells through functional analysis of gene modules.

This study identifies significant false negatives and blind spots in CRISPR knockout screens, showing that many genes are functionally buffered and never detected as essential.

The paper constructs a coessentiality network from CRISPR knockout screens to infer gene function and reveal hierarchical cell organization.