RAS-mutant clones drive extramedullary acute myeloid leukemia
Panagiota Chaida, Julia Frimmel, Lara Hopfer, Bianca Perfler, Eva Gruden, Akshaya Kailasnathan, KARIN LIND, Bernadette Bramreiter, Johannes Foßelteder, Sonja Wurm, Jennifer Neiss, Stefan Koeck, Dominik Georg Friedrich Wolf, Gudrun Ratzinger, Nassim Ghaffari‐Tabrizi‐Wizsy, , Armin Zebisch
This study identifies RAS mutations as a key driver of extramedullary acute myeloid leukemia, showing their role in promoting leukemic cell migration and infiltration through the JAML-PI3K/AKT pathway.
bioRxiv · Apr 9, 2026 · PreprintCancer Biology