Dominik Georg Friedrich Wolf

RAS-mutant clones drive extramedullary acute myeloid leukemia

This study identifies RAS mutations as a key driver of extramedullary acute myeloid leukemia, showing their role in promoting leukemic cell migration and infiltration through the JAML-PI3K/AKT pathway.

NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms

This study shows that NLRP3 inflammasome activation drives JAK2V617F mutant myeloproliferative neoplasms by promoting inflammation, platelet production, and fibrosis, and that its inhibition can reverse disease features.

Deep single-cell immune and signaling profiles predict long term therapy response in chronic myeloid leukemia within hours

The paper uses mass cytometry to analyze immune and signaling profiles in CML patients within hours of TKI treatment to predict 12-month treatment response.

The CCR4/CCL17 axis drives intestinal acute Graft versus Host disease after allogeneic bone marrow transplantation

This study shows that the CCR4/CCL17 axis promotes intestinal acute GvHD by recruiting T cells and increasing Gata3 expression, and identifies ruxolitinib as a potential therapeutic.

Network efficiency predicts resilience to cognitive decline in elderly at risk for Alzheimer's

This study finds that higher white matter network efficiency is associated with greater resilience to cognitive decline in elderly individuals, independent of amyloid and tau pathology.