Andreas Reinisch

This study identifies RASmutEZH2inact as a distinct CMML subgroup with increased MEK inhibitor sensitivity due to MAPK/ERK hyperactivation.

The paper describes a method using self-organized hemanoids from human iPSCs to generate RBCs, showing they mimic extraembryonic hematopoiesis.

This study identifies RAS mutations as a key driver of extramedullary acute myeloid leukemia, showing their role in promoting leukemic cell migration and infiltration through the JAML-PI3K/AKT pathway.

This study characterizes a humanized in vivo bone marrow model, hOss, showing its impact on human hematopoietic development and clonal interactions.