This study identifies RAS mutations as a key driver of extramedullary acute myeloid leukemia, showing their role in promoting leukemic cell migration and infiltration through the JAML-PI3K/AKT pathway.

bioRxiv · Apr 9, 2026 · PreprintCancer Biology

Proteomic and Metabolomic Profiling of Archaeal Extracellular Vesicles from the Human Gut

Viktoria Weinberger, Barbara Darnhofer, Himadri B Thapa, Polona Mertelj, Régis Stentz, Emily J. Jones, Gerlinde Grabmann, Rokhsareh Mohammadzadeh, Tejus Shinde, Christina Karner, Jennifer Ober, Rokas Juodeikis, Dominique Pernitsch, Kerstin Hingerl, Tamara Zurabishvili, , Christine Moissl‐Eichinger

This study profiles proteomic and metabolomic features of archaeal extracellular vesicles from the human gut, revealing their structural similarity to bacterial EVs and their potential to modulate immune responses.

Nature Communications · Jun 3, 2025Peer-reviewedMicrobiology

Global analysis of protein arginine methylation

Fangrong Zhang, Jakob Kerbl-Knapp, Maria J. Rodríguez Colman, Andreas Meinitzer, Therese Macher, Nemanja Vujić, Sandra Fasching, Evelyne Jany-Luig, Melanie Korbelius, Katharina Barbara Kuentzel, Maximilian Mack, Alena Akhmetshina, Anita Pirchheim, Margret Paar, Beate Rinner, , Tobias Madl

The paper develops an NMR-based method to quantify global protein arginine methylation levels across various biological samples and demonstrates its prevalence and modulation in health and disease.

Cell Reports Methods · Jan 1, 2021Peer-reviewedSystems Biology