High-throughput LacZ/CPRG screen identifies novel potential antibiotics targeting Gram-negative bacterial envelopes to combat resistance
Fardin Ghobakhlou, Larbi Mokhtari, Tom A. Pfeifer, Catherine Paradis‐Bleau
This study identifies 57 compounds, including three non-antibiotics, that disrupt Gram-negative bacterial envelopes using a LacZ/CPRG reporter assay, with alexidine showing the strongest activity.
bioRxiv · Apr 9, 2025 · PreprintMicrobiology