A FOXA1/SPDEF Co-regulatory Axis Drives ERBB2 and Suppresses TEAD/YAP-Driven EMT to Maintain Luminal Identity in HER2+ Breast Cancer
Jaekwang Jeong, Jong Won Lee, Seungsoo Kim, Jaechul Lim, Jaehun Shin, Kwangmin Yoo, Jonghun Kim, Yoshiaki Tanaka, Hyun Seop Tae, Lark Kyun Kim, In‐Hyun Park, Samir Zaidi, John J. Wysolmerski, Jungmin Choi
This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.
bioRxiv · Apr 16, 2024 · PreprintCancer Biology