John J. Wysolmerski

This study shows that diet-induced changes in phospholipid composition affect ferroptosis sensitivity and tumorigenesis in pancreatic cancer.

The paper develops a floxed Gabbr2 mouse model that recapitulates the phenotype of global Gabbr2 knockout mice when Cre is expressed, enabling study of GABBR2 loss in specific cell types.

The paper shows Erbin interacts with NHERF1 and Ezrin to stabilize a membrane HER2 signaling complex in HER2-positive breast cancer, enhancing HER2 stability and transforming ability.

This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.

This study shows DKK2 is required for colon cancer metastasis by generating cancer cells with Paneth cell properties through HNF4A regulation.

This study shows that hypercalcemia from tumor-secreted PTHrP activates hindbrain circuits linked to anorexia, and blocking hypercalcemia prevents these effects.