Simultaneous pathway engagement of translation in astrocytes, circadian rhythm in GABAergic neurons and cytoskeleton in glutamatergic neurons precede electroencephalographic changes in neurodegenerative prion disease
Lech Kaczmarczyk, Melvin Schleif, Lars Dittrich, Rhîannan H. Williams, Maruša Koderman, Vikas Bansal, Ashish Rajput, Theresa Schulte, Maria Jonson, Clemens Krost, Fabio J. Testaquadra, Stefan Bonn, Walker S. Jackson
The paper identifies early translatome changes in specific neural cell types before EEG and neuropathological signs of prion disease in mice.
PLoS Pathogens · Aug 12, 2022Peer-reviewedNeuroscience