Rhîannan H. Williams

Cortex-Wide Preservation of Multi-Stimulus Information across Degrees of Network Synchronization

The paper decodes stimulus identity and network state from calcium imaging in mice across different anesthesia states, showing preserved stimulus information even during deep anesthesia.

Long-term adaptation of prefrontal circuits in a mouse model of NMDAR hypofunction

This study investigates the long-term effects of subchronic PCP treatment on prefrontal circuits in mice, revealing alterations in cognitive performance, gamma oscillations, and synaptic connectivity associated with schizophrenia endophenotypes.

Simultaneous pathway engagement of translation in astrocytes, circadian rhythm in GABAergic neurons and cytoskeleton in glutamatergic neurons precede electroencephalographic changes in neurodegenerative prion disease

The paper identifies early translatome changes in specific neural cell types before EEG and neuropathological signs of prion disease in mice.

Coupling of oxytocin and cholecystokinin pathways in the hypothalamus is required for gut-to-brain homeostatic feeding control

This study shows that oxytocin and cholecystokinin pathways in hypothalamic neurons are critical for gut-to-brain feeding control, with their disruption leading to hyperphagic obesity.

Collagen VI regulates motor circuit plasticity and motor performance by cannabinoid modulation

This study identifies a synaptic mechanism linking collagen VI to motor control through cannabinoid receptor interaction and shows that CB1R agonists can improve motor performance in a dystonia mouse model.