Profound CD4+ T-Cell Reprogramming by Melphalan-Driven Oxidative Stress in High-Risk Multiple Myeloma
Mara John, Nazia Afrin, Xiang Zhou, Emilia Stanojkovska, Hanna Fischer, Maximilian J Krämer, Werner Schmitz, Lars Grundheber, Moutaz Helal, Arpa Aintablian, Silvia Nerreter, Cornelia Vogt, Shilpa Kurian, Angelika Wolf, Sarah Wiethe, , Angela Riedel
This study shows that melphalan treatment causes oxidative stress in T cells, reducing CD4+ naive T cells in high-risk multiple myeloma patients.
bioRxiv · Jun 11, 2026 · PreprintCancer Biology