Author

Jacquelyn Ann Brown

University of PittsburghORCID 0000-0002-2002-3010Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Albert GoughiD· 1 shared Alejandro Soto–GutiérreziD· 1 shared Andrew M. SterniD· 1 shared Celeste E. Reese· 1 shared D. Lansing TayloriD· 1 shared Dillon C. GavlockiD· 1 shared Gregory M LaRocca· 1 shared Iris Plá-Palacín· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCell Biology

Albert GoughORCID

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2 papers

Recent·Most cited

Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy

Mengying Xia, Mahboubeh Varmazyad, Iris Plá-Palacín, Dillon C. Gavlock, Richard DeBiasio, Gregory M LaRocca, Celeste E. Reese, Rodrigo Machado Florentino, Lanuza A.P. Faccioli, Jacquelyn Ann Brown, Lawrence A. Vernetti, Mark E. Schurdak, Andrew M. Stern, Albert Gough, Jaideep Behari, , Mark T. Miedel

This study uses a human liver microphysiology system to compare the effects of PNPLA3 variants on MASLD progression and drug response.

Frontiers in Cell and Developmental Biology · Sep 11, 2024Peer-reviewedCell Biology

Rescue of Impaired Blood-Brain Barrier in Tuberous Sclerosis Complex Patient Derived Neurovascular Unit

Jacquelyn Ann Brown, Shannon L. Faley, Monika Judge, Patricia Ward, Rebecca A. Ihrie, Robert Carson, Laura C. Armstrong, Mustafa Şahin, John P. Wikswo, Kevin C. Ess, M. Diana Neely

This study uses patient-derived neurovascular units to show that TSC2 mutations impair BBB function, which can be rescued by wild-type astrocytes or rapamycin treatment.

Journal of Neurodevelopmental Disorders · May 23, 2024Peer-reviewedNeuroscience