Alphavirus replicons encoding IFNγ enhance cancer virotherapy by overcoming macrophage-mediated suppression
Laura Horvathova, Priscilla Kinderman, Thijs Janzen, Baukje Nynke Hoogeboom, Franz J. Weissing, Nadine van Montfoort, Toos Daemen, Darshak Bhatt
This study shows that alphavirus replicons encoding IFNγ enhance cancer virotherapy by overcoming macrophage-mediated suppression through T-cell activation and macrophage reprogramming.
iScience · Sep 10, 2025Peer-reviewedImmunology