ImmunologyiSciencePeer-reviewed
Alphavirus replicons encoding IFNγ enhance cancer virotherapy by overcoming macrophage-mediated suppression
Laura Horvathova, Priscilla Kinderman, Thijs Janzen…·Darshak Bhatt
This study shows that alphavirus replicons encoding IFNγ enhance cancer virotherapy by overcoming macrophage-mediated suppression through T-cell activation and macrophage reprogramming.