Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation.
Niran Hadad, Archana Unnikrishnan, Jordan A. Jackson, Dustin R. Masser, Laura Otalora, David R. Stanford, Arlan G Richardson, Willard M. Freeman
This study shows that caloric restriction reduces age-related DNA methylation changes in the hippocampus of mice, including both CG and non-CG sites, and introduces CR-specific methylation patterns linked to gene expression changes.
Neurobiology of Aging · Jul 1, 2018Peer-reviewedNeuroscience