The paper shows that early life DNA methylation patterns predict age-related transcriptome changes in mice, supporting the developmental origins of disease hypothesis.

Epigenetics & Chromatin · Oct 8, 2019Peer-reviewedGenomics

Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation.

Niran Hadad, Archana Unnikrishnan, Jordan A. Jackson, Dustin R. Masser, Laura Otalora, David R. Stanford, Arlan G Richardson, Willard M. Freeman

This study shows that caloric restriction reduces age-related DNA methylation changes in the hippocampus of mice, including both CG and non-CG sites, and introduces CR-specific methylation patterns linked to gene expression changes.

Neurobiology of Aging · Jul 1, 2018Peer-reviewedNeuroscience

Sexually divergent DNA methylation programs with hippocampal aging

Dustin R. Masser, Niran Hadad, Hunter L. Porter, Colleen A. Mangold, Archana Unnikrishnan, Matthew M. Ford, Cory B. Giles, Constantin Georgescu, Mikhail G. Dozmorov, Jonathan D. Wren, Arlan G Richardson, David R. Stanford, Willard M. Freeman

This study identifies sexually divergent DNA methylation changes in mouse and human hippocampus with aging, revealing sex as a key factor in epigenomic aging.

Aging Cell · Sep 25, 2017Peer-reviewedNeuroscience