Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition
Georg Petzold, Pablo Gaínza, Stefano Annunziato, Ilaria Lamberto, Peter Trenh, Laura A. McAllister, Bradley DeMarco, Laura Schwander, R.D. Bunker, Mary Zlotosch, Rohitha Sriramaratnam, Samuel Gilberto, Gerasimos Langousis, Etienne J. Donckèle, Chao Quan, , Sharon A. Townson
The paper predicts over 1,400 CRBN-compatible β-hairpin G-loop proteins and validates 22 neosubstrates, redefining rules for molecular glue-induced degradation.
Science · Jul 3, 2025Peer-reviewedBiochemistry