Author

Gian Marco De Donatis

Boston FoundationORCID 0000-0002-7684-2189Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Amine SadokiD· 2 shared Bernhard FaschingiD· 2 shared Bradley DeMarco· 2 shared Camille Staehly· 2 shared Chao QuaniD· 2 shared Débora BonenfantiD· 2 shared Etienne J. DonckèleiD· 2 shared Georg PetzoldiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Amine SadokORCID

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Author profile →

2 papers

Recent·Most cited

Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition

Georg Petzold, Pablo Gaínza, Stefano Annunziato, Ilaria Lamberto, Peter Trenh, Laura A. McAllister, Bradley DeMarco, Laura Schwander, R.D. Bunker, Mary Zlotosch, Rohitha Sriramaratnam, Samuel Gilberto, Gerasimos Langousis, Etienne J. Donckèle, Chao Quan, , Sharon A. Townson

The paper predicts over 1,400 CRBN-compatible β-hairpin G-loop proteins and validates 22 neosubstrates, redefining rules for molecular glue-induced degradation.

Science · Jul 3, 2025Peer-reviewedBiochemistry

Molecular surface mimicry enables CRBN to target G3BP2 for degradation

Stefano Annunziato, Chao Quan, Etienne J. Donckèle, Ilaria Lamberto, R.D. Bunker, Mary Zlotosch, Laura Schwander, A. Murthy, L. Wiedmer, Camille Staehly, Michelle Matysik, Samuel Gilberto, Despina Kapsitidou, Daric Wible, Gian Marco De Donatis, , Georg Petzold

This study identifies a novel binding mechanism of G3BP2 to CRBN through an unconventional site, expanding the understanding of CRBN's neosubstrate recognition.

bioRxiv · Apr 30, 2025 · PreprintMolecular Biology