Amine Sadok

This study develops VHL molecular glues that selectively degrade caspase-2, expanding the substrate range of VHL-based degraders and providing tools to study caspase-2's role in apoptosis and stress.

The paper predicts over 1,400 CRBN-compatible β-hairpin G-loop proteins and validates 22 neosubstrates, redefining rules for molecular glue-induced degradation.

This study identifies a novel binding mechanism of G3BP2 to CRBN through an unconventional site, expanding the understanding of CRBN's neosubstrate recognition.