ER stress relief drives beta cell proliferation
Stephanie Bourgeois, Annelore Van Mulders, Yves Heremans, Gunter Leuckx, Lien Willems, Sophie Coenen, Laure Degroote, Julie Pierreux, Daliya Kancheva, Isabelle Scheyltjens, Kiavash Movahedi, Françoise Carlotti, Eelco de Koning, Xiaoyan Yi, Chiara Vinci, , Willem Staels
The paper shows that ER stress relief in beta cells promotes proliferation, independent of vascular recovery, by using transgene overexpression and chemical induction.
bioRxiv · Sep 6, 2024 · PreprintMolecular Biology