Eelco J.P. de Koning

This study shows that R-BHB alters human islet cell composition and identity, while S-BHB does not, suggesting ketone metabolism influences beta cell function.

The paper constructs a single-cell multiomics atlas of the human pancreas across development, health, and T2D, identifying plastic cell states and lineage trajectories.

The paper infers post-transcriptional regulatory mechanisms in human islets using cell type-specific eQTLs from single-cell RNA-seq data, linking variants to biological processes in health and disease.

The paper shows that ER stress relief in beta cells promotes proliferation, independent of vascular recovery, by using transgene overexpression and chemical induction.

The paper identifies splicing QTLs in human pancreatic islets that contribute to type 2 diabetes susceptibility by affecting gene splicing and revealing novel molecular mechanisms.

This study identifies miR-125b-5p as a glucose-regulated miRNA that negatively regulates β-cell function by modulating organelle dynamics and insulin secretion.

GateID combines single-cell transcriptomics with FACS to purify cell types without specific antibodies or transgenes.

The paper links diabetes-associated enhancers with their target genes using 3D chromatin architecture in human pancreatic islets, revealing genetic variants that impact insulin secretion heritability.