Developmental PBDE exposure impairs histamine release from mast cells by altering granule maturation and calcium signaling in adult male and female mice
Jared Franges, Lauren Malinowski, Chathuri De Alwis, Taylor Doolittle, Hannahlee Dixon, Yang Tang, Helen Watson, Jasmine Peace, Dereje D. Jima, Leslie A. Sombers, Gregory McCarthy, Heather B. Patisaul, Heather M. Stapleton, Natalia Duque‐Wilckens
This study shows developmental PBDE exposure impairs mast cell function in adult mice by disrupting granule maturation and calcium signaling, leading to reduced histamine release.
bioRxiv · Jun 28, 2025 · PreprintPharmacology & Toxicology