Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus
Seung Chul Choi, Yong Ge, Ahmed Samir Elshikha, Yuk Pheel Park, Cenxiao C. Fang, Milind V. Joshi, Maria Montes de Oca Arena, Lauren Padilla, Yanan Zhu, William L. Clapp, Eric S. Sobel, Mansour Mohamadzadeh, Laurence M Morel
This study shows that inhibiting glycolysis with 2DG reduces TFH cell expansion and autoantibody production in lupus-prone mice, with potential therapeutic implications for SLE.
Cell Reports · Nov 22, 2025Peer-reviewedImmunology