Yanan Zhu

Multimodal Behavior Scoring quantifies depression-like severity across chronic stress models and identifies stress-resilient mice

The paper introduces MBS, a multimodal scoring system to quantify depression-like severity in stressed mice, identifying resilient subpopulations and behavioral patterns across stress models.

Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus

This study shows that inhibiting glycolysis with 2DG reduces TFH cell expansion and autoantibody production in lupus-prone mice, with potential therapeutic implications for SLE.

Development of noninvasive biomarkers of response to proteasome inhibitor therapy (ixazomib) by imaging disrupted protein homeostasis in mouse models of solid tumors

This study uses CEST MRI to noninvasively monitor proteasome inhibitor response in mouse tumor models, showing increased CEST signals with higher drug doses and varying tumor sensitivity.