UFMylation of 14-3-3ϵ coordinates MAVS signaling complex assembly to promote antiviral innate immune induction
Isaura Vanessa Gutierrez, Moonhee Park, Lauren Sar, Ryan E. Rodriguez, Hannah M. Schmidt, Daltry L. Snider, Gabriella Torres, Kenneth Matthew Scaglione, Stacy M. Horner
This study identifies UFMylation sites on 14-3-3ϵ that regulate MAVS complex assembly and RIG-I signaling to enhance antiviral innate immunity.
bioRxiv · Mar 19, 2025 · PreprintImmunology