Stacy M. Horner

Modulator Resolves Transcript-, Allele-, and Condition-associated RNA Modification Differences from Direct RNA Sequencing

Modulator processes nanopore direct-RNA sequencing data to differentiate transcript-, allele-, and condition-associated RNA modifications, improving the analysis of RNA modifications in single molecules.

The m6A methyltransferase complex protein VIRMA engages hepatitis C virus RNA through a WTAP-independent mechanism

This study identifies VIRMA as an HCV RNA-targeting factor that recruits the m6A-MTC to the viral genome through a WTAP-independent mechanism.

Transcript architecture sets the m6A landscape: CSTF2 and CSTF2T reshape m6A through cleavage-dependent and -independent mechanisms

The paper identifies CSTF2 and CSTF2T as factors that shape the m6A landscape through cleavage-dependent and -independent mechanisms by altering transcript architecture and polyadenylation sites.

IFIT3 Associates with m⁶A-Modified RNA to Restrict Hepatitis C Virus Infection

This paper identifies IFIT3's preference for m⁶A-modified RNA to restrict HCV infection and reveals structural regions critical for RNA binding and antiviral activity.

A small cationic probe for accurate, punctate discovery of RNA tertiary structure

The paper introduces a small cationic probe, TMO, to detect RNA tertiary structures by identifying electronegative motifs that react selectively with TMO, revealing functional tertiary interaction sites.

UFMylation promotes orthoflavivirus infectious particle production

This study shows UFMylation enhances orthoflavivirus infection by promoting virion assembly, but not RNA replication or translation.

UFMylation of 14-3-3ϵ coordinates MAVS signaling complex assembly to promote antiviral innate immune induction

This study identifies UFMylation sites on 14-3-3ϵ that regulate MAVS complex assembly and RIG-I signaling to enhance antiviral innate immunity.

FTO suppresses STAT3 activation and modulates proinflammatory interferon-stimulated gene expression

The paper shows FTO suppresses proinflammatory ISG expression by inhibiting STAT3 activation during the type I IFN response.

Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing

The paper uses direct RNA long-read sequencing to show m6A modifications on adenovirus RNA are necessary for efficient splicing.

Limits in the detection of m6A changes using MeRIP/m6A-seq

This study evaluates the reproducibility of m6A peak detection and changes using MeRIP-seq and finds limited consistency across studies.

Altered m6A modification of specific cellular transcripts affects Flaviviridae infection

This study shows that Flaviviridae viruses alter m6A modification of specific host transcripts, affecting viral infection through changes in translation and splicing.

An atlas of genetic variation for linking pathogen-induced cellular traits to human disease

The paper links genetic variation to pathogen-induced cellular traits and disease by integrating GWAS data with clinical and experimental validation.