David J. Hughes

This study investigates the ISG15-USP18-STAT2 inhibitory complex's structure and function using AlphaFold and biochemical methods, revealing critical residues and patient mutations affecting its interaction.

The paper identifies a novel CRTC-dependent viral sensing pathway that promotes interleukin-11 production during viral infection.

The paper develops a highly sensitive Renilla luciferase-based reporter cell line to detect IFN types I-III and neutralizing antibodies.

This paper develops a hybrid, multiscale, individual-based model to study SARS-CoV-2 infection spread and immune response, focusing on macrophages and their interactions with viral dynamics and cytokines.