FET fusion proteins reshape splicing factor networks to drive oncogenic alternative splicing
Loïc Ongena, Eva Lucarelli, Laurence Dubois, Jonathan Bruyr, Lianghao Mao, Florian H. Geyer, Florencia Cidre‐Aranaz, Thomas G. P. Grünewald, Ashok Kumar Jayavelu, Yiyun Zhang, Akshay Bhinge, Didier Vertommen, Franck Dequiedt
This study shows FET fusion proteins regulate alternative splicing in sarcomas through RNA-binding protein networks, independent of their transcriptional activity, and identifies actionable splicing targets.
bioRxiv · Aug 31, 2026 · PreprintMolecular Biology