Didier Vertommen

This study identifies PTPRF as a stress-responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells by linking metabolic stress to actin reorganization.

This study shows FET fusion proteins regulate alternative splicing in sarcomas through RNA-binding protein networks, independent of their transcriptional activity, and identifies actionable splicing targets.

This study attempts to reconstitute the transient Prdx2:STAT3 redox-relay complex in vitro but finds it challenging due to its redox-dependent nature and susceptibility to hyperoxidation.

This study maps stage-dependent tau post-translational modifications across Alzheimer's disease progression, revealing early phosphorylation and later ubiquitination events associated with tau aggregation.

This study identifies a unique metabolic plasticity mechanism in AML cells through protein S-acylation, which is inhibited by TOFA and a glutaminase inhibitor combination.

This study identifies the C-terminal domain (CTD) of BSAP-1 as the receptor-binding region, showing its role in specificity and potential for developing new tools.

This study shows that cardiovirus L protein disrupts nucleocytoplasmic trafficking, leading to PKR inhibition by sequestering PKR in nucleoli and releasing nuclear RNA-binding proteins into the cytosol.

This study identifies conserved phosphorylatable residues in motif G of viral RdRps that inhibit polymerase activity and suggests they as targets for antiviral drugs.

This study identifies a circadian clock-controlled signaling pathway that drives hepatic stellate cell activation in liver fibrosis, offering potential drug targets and a basis for chronotherapeutic strategies.

The paper identifies LxxLL motifs in NIPBL that regulate its interaction with MAU2 and steroid receptors, forming a ternary complex with GR to facilitate enhancer localization of cohesin.

The paper shows that eukaryotic Prx1/AhpC-type peroxiredoxins form heterooligomers, which modulate their structure and stability, challenging the previous belief in homooligomerization.

The paper shows that deleting both NT5C1A and NT5C2 in mice lowers blood sugar by improving muscle insulin response and reducing liver glucose production.

This study identifies 225 redox-active nuclear proteins in Arabidopsis, including GCN5, modified by sulfenylation under oxidative stress, revealing their functional impact on protein interactions.

This study uses Thermal Proteome Profiling to identify proteomic responses to localized H2O2 production in different cellular compartments.

This study identifies AtMED25 as a key mediator of ERFVII-controlled hypoxia responses in Arabidopsis, showing its role in transcriptional regulation under low-oxygen conditions.

This study introduces a method combining plasma prefractionation and DIA to improve proteome coverage and depth, enabling robust biomarker identification in a COVID-19 cohort.

The paper identifies and characterizes Sut1, a tyrosine kinase in Sulfolobus acidocaldarius, showing it phosphorylates tyrosine residues in vitro and belongs to a novel archaeal kinase family.

This paper identifies a non-enzymatic HDAC inhibitor with anti-tumor and anti-psychedelic effects, showing reduced gene modulation compared to enzymatic inhibitors.

The paper shows that dimeric orientations of C99 influence γ-secretase cleavage lines, affecting Aβ42 processing and gene transcription.