Author

Jonathan Bruyr

University of Liège

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Franck DequiedtiD· 3 shared Didier VertommeniD· 2 shared Aaron D. Richardson· 1 shared Akshay BhingeiD· 1 shared Alejandro HochkoeppleriD· 1 shared Alessandra StefaniD· 1 shared Alex K. ShalekiD· 1 shared Alexandra Bacquelaine VelosoiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersMolecular Biology

Franck DequiedtORCID

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3 papers

Recent·Most cited

FET fusion proteins reshape splicing factor networks to drive oncogenic alternative splicing

Loïc Ongena, Eva Lucarelli, Laurence Dubois, Jonathan Bruyr, Lianghao Mao, Florian H. Geyer, Florencia Cidre‐Aranaz, Thomas G. P. Grünewald, Ashok Kumar Jayavelu, Yiyun Zhang, Akshay Bhinge, Didier Vertommen, Franck Dequiedt

This study shows FET fusion proteins regulate alternative splicing in sarcomas through RNA-binding protein networks, independent of their transcriptional activity, and identifies actionable splicing targets.

bioRxiv · Aug 31, 2026 · PreprintMolecular Biology

The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish

Alexandra Bacquelaine Veloso, Anouk Bleuart, Louise Conrard, Tanguy Orban, Jonathan Bruyr, Pauline Cabochette, Raoul F. V. Germano, Giel Schevenels, Alice Bernard, Egor Zindy, Sofie Demeyer, Benoît Vanhollebeke, Franck Dequiedt, Maud Martin

This study identifies Sorbs1's role in zebrafish lymphatic and venous vessel development, showing it regulates cytoskeleton dynamics and BMP signaling, distinct from Vegfc pathways.

BMC Biology · Feb 27, 2024Peer-reviewedDevelopmental Biology

Expanding the HDAC druggable landscape beyond enzymatic activity

Julien Olivet, Soon Gang Choi, Salvador Sierra, Tina M. O’Grady, Mario de la Fuente Revenga, Florent Laval, Vladimir V. Botchkarev, Christoph Gorgulla, Paul W. Coote, Jérémy Blavier, Ezekiel A. Geffken, Jimit Lakhani, Kijun Song, Zoe C. Yeoh, Bin Hu, , Marc Vidal

This paper identifies a non-enzymatic HDAC inhibitor with anti-tumor and anti-psychedelic effects, showing reduced gene modulation compared to enzymatic inhibitors.

bioRxiv · Dec 7, 2022 · PreprintMolecular Biology