A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function
Rebecca L. Brouillette, Frédérique Lussier, Émile Breault, Nathan Meneboo, Malihe Hassanzadeh, Victoria Tremblay, Magali Chartier, Élora Midavaine, Laurence Ulrich, Jérôme Côté, Véronique Blais, Christine E. Mona, Jean‐Michel Longpré, Michel Grandbois, Pierre‐Luc Boudreault, , Philippe Sarret
This paper describes a pepducin derived from NTS1 that acts as a biased allosteric modulator, preferentially activating G proteins over β-arrestin and inhibiting receptor internalization.
Acta Pharmaceutica Sinica B · Dec 31, 2025Peer-reviewedPharmacology & Toxicology