Élora Midavaine

Automated compartment-based quantification reveals distinct patterns of cutaneous innervation with aging and microbial colonization

The paper develops an automated image analysis pipeline to quantify cutaneous innervation in different skin compartments, revealing age and microbial effects on nerve area and length.

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function

This paper describes a pepducin derived from NTS1 that acts as a biased allosteric modulator, preferentially activating G proteins over β-arrestin and inhibiting receptor internalization.

Meningeal Regulatory T cell-derived enkephalin gates nociception

This study identifies meningeal regulatory T cells (mTregs) expressing enkephalin that modulate mechanical pain sensitivity in female mice via a sex hormone-dependent opioid receptor mechanism.

CCR2 silencing in sensory neurons blocks bone cancer progression

This study shows that silencing CCR2 in sensory neurons blocks bone cancer progression and alleviates pain by disrupting neuropeptide-driven tumor growth.

CCR2-targeting pepducins reduce T cell-nociceptor interaction driving bone cancer pain

The paper shows that CCR2-targeting pepducin PP101 reduces bone cancer pain by inhibiting T cell infiltration and neuroimmune communication in dorsal root ganglia without adverse effects.

Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch

The paper shows that overexpression of tetracycline transactivator in keratinocytes causes neuropathic itch in mice, which can be reversed by inhibiting Gi signaling or ablating TRPV1 neurons.