Philippe Sarret

This paper describes a pepducin derived from NTS1 that acts as a biased allosteric modulator, preferentially activating G proteins over β-arrestin and inhibiting receptor internalization.

This study shows that silencing CCR2 in sensory neurons blocks bone cancer progression and alleviates pain by disrupting neuropeptide-driven tumor growth.

The paper shows that CCR2-targeting pepducin PP101 reduces bone cancer pain by inhibiting T cell infiltration and neuroimmune communication in dorsal root ganglia without adverse effects.

This study shows that mice can brake and turn during optogenetic stimulation of the MLR, with speed and turn angle scaling to pre-turn speed.

The paper shows neurotensin and dynorphin oppositely modulate CeA inhibition of oval BNST neurons in male mice through distinct receptors.