Pharmacokinetics and Central Accumulation of Delta-9-Tetrahydrocannabinol (THC) and its Bioactive Metabolites are Influenced by Route of Administration and Sex
Samantha L. Baglot, Catherine Hume, Gavin N. Petrie, Robert J. Aukema, Savannah H. M. Lightfoot, Laine M. Grace, Ruokun Zhou, Linda A. Parker, Jong M. Rho, Stephanie L. Borgland, Ryan J. McLaughlin, Laurent Brechenmacher, Matthew N. Hill
This study compares THC and metabolite pharmacokinetics in rats after inhalation vs. injection, finding route-specific differences in brain and blood levels and hypothermic responses.
Scientific Reports · Dec 14, 2021Peer-reviewedNeuroscience