Author

Jong M. Rho

University of CalgaryORCID 0000-0001-9886-9924Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 5 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Organism:zebrafish· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2

Frequent Co-Authors

Deborah Marie KurraschiD· 4 shared Cristiane Lucia Rodriguez de la Hoz· 2 shared Deepika Dogra· 2 shared Kingsley Ibhazehiebo· 2 shared Mitchell Kesler· 2 shared Alexandra K. WalliD· 1 shared Amit Jaiswal· 1 shared Ananya S. AchantaiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersNeuroscience

Deborah Marie KurraschORCID

Mutual co-authors in cluster

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6 papers

Recent·Most cited

NeurosciencebioRxivPreprintMay 13, 2025

Inhibition of phosphodiesterase 4B as a novel therapeutic strategy for the treatment of refractory epilepsy

Cassandra D. Kinch, Mitchell Kesler, Deepika Dogra…·Deborah Marie Kurrasch

SN-2000, a novel PDE4B inhibitor, reduces seizure activity and shows psychiatric-neutral and pro-cognitive properties in preclinical models.

1 citation

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NeurosciencebioRxivPreprintApr 11, 2025

A ketogenic diet mitigates hippocampal astrogliosis in epileptic brain

Jae Hyouk Choi, Jae Mun Kim, Shuhe Wang…·Jong M. Rho

This study shows that a ketogenic diet reduces hippocampal astrogliosis and restores astrocytic potassium buffering in a mouse model of epilepsy.

DOI 10.1101/2025.04.11.647636

mousebulk RNA-seq

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NeuroscienceNeuropharmacologyPeer-reviewedMar 21, 2023

Sudden unexpected death in epilepsy is prevented by blocking postictal hypoxia

Antis G. George, Jordan S. Farrell, Roberto Colangeli…·G. Campbell Teskey

This study shows that blocking postictal hypoxia prevents SUDEP in mice by preventing seizure-induced vasoconstriction.

21 citations

mouseexperimental assay

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Molecular BiologybioRxivPreprintOct 3, 2022

The Ketogenic Diet Metabolite β-Hydroxybutyrate Promotes Mitochondrial Elongation via Deacetylation in HeLa Cells and Improves Autism-like Behavior in Zebrafish

Golam Mezbah Uddin, Rachel Lacroix, Mashiat Zaman…·Timothy E. Shutt

3 citations

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NeurosciencebioRxivPreprintSep 28, 2022

kcna1a mutant zebrafish as a model of episodic ataxia type 1 and epilepsy

Deepika Dogra, Paola L. Meza Santoscoy, Renata Rehak…·Deborah Marie Kurrasch

This paper uses zebrafish kcna1a-/- mutants to model EA1 and epilepsy, showing ataxia-like behaviors, brain hyperexcitability, and responsiveness to carbamazepine.

DOI 10.1101/2022.09.28.509973

zebrafishexperimental assay

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NeuroscienceScientific ReportsPeer-reviewedDec 14, 2021

Pharmacokinetics and Central Accumulation of Delta-9-Tetrahydrocannabinol (THC) and its Bioactive Metabolites are Influenced by Route of Administration and Sex

Samantha L. Baglot, Catherine Hume, Gavin N. Petrie…·Matthew N. Hill

This study compares THC and metabolite pharmacokinetics in rats after inhalation vs. injection, finding route-specific differences in brain and blood levels and hypothermic responses.

100 citationstop 1%

ratexperimental assay

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