Ubiquitin-dependent recruitment of SLFN11 to chromatin is regulated by deubiquitinase and RNF168
Ukhyun Jo, Daiki Taniyama, Gianluca Pegoraro, Ying Wu, Shar-yin Huang, Craig J. Thomas, Laurent Ozbun, Andy D. Tran, Liton Saha, Junko Murai, Yves G. Pommier
The paper identifies that DUB inhibitors and RNF168-mediated ubiquitylation drive SLFN11 chromatin recruitment, particularly at promoters, and that this process is suppressed by TAK243.
bioRxiv · Mar 27, 2026 · PreprintCell Biology