METTL3 alters capping enzyme expression and its activity on ribosomal proteins
Daniel del Valle Morales, Giulia Romano, Giovanni Nigita, Michela Saviana, Alessandro La Ferlita, Patricia Le, Rachel Brown, Lavender Micalo, Howard Y. Li, Patrick S. Nana-Sinkam, Mario Acunzo
This study investigates how METTL3 regulates RNGTT expression and activity, finding that METTL3 knockdown destabilizes RNGTT mRNA and reduces protein expression, with downstream effects on ribosomal protein capping and mTOR pathway disruption.
Scientific Reports · Nov 12, 2024Peer-reviewedMolecular Biology