Author

Patrick S. Nana-Sinkam

Virginia Commonwealth UniversityORCID 0009-0001-7635-6893Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

Daniel del Valle MoralesiD· 2 shared Giovanni NigitaiD· 2 shared Giulia RomanoiD· 2 shared Mario AcunzoiD· 2 shared Michela SavianaiD· 2 shared Alessandro La FerlitaiD· 1 shared Howard Y. LiiD· 1 shared Lavender Micalo· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Daniel del Valle MoralesORCID

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2 papers

Recent·Most cited

A multi-omics approach to identify the impact of miR-411ed on NSCLC TKI resistance

Daniel del Valle Morales, Giulia Romano, Michela Saviana, Patrick S. Nana-Sinkam, Giovanni Nigita, Mario Acunzo

This study uses a multi-omics approach to show miR-411ed enhances Osimertinib efficacy in TKI-resistant NSCLC by targeting STAT3 and altering interferon and ERK/MAPK pathways.

bioRxiv · Apr 3, 2026 · PreprintCancer Biology

METTL3 alters capping enzyme expression and its activity on ribosomal proteins

Daniel del Valle Morales, Giulia Romano, Giovanni Nigita, Michela Saviana, Alessandro La Ferlita, Patricia Le, Rachel Brown, Lavender Micalo, Howard Y. Li, Patrick S. Nana-Sinkam, Mario Acunzo

This study investigates how METTL3 regulates RNGTT expression and activity, finding that METTL3 knockdown destabilizes RNGTT mRNA and reduces protein expression, with downstream effects on ribosomal protein capping and mTOR pathway disruption.

Scientific Reports · Nov 12, 2024Peer-reviewedMolecular Biology