Alessandro La Ferlita

The paper identifies recurrent copy-number alterations in RCC brain metastases and shows their association with poor prognosis and metastatic potential across multiple cancers.

The paper identifies GREB1 as upregulated in colorectal cancer ovarian metastases compared to peritoneal metastases and primary tumors, suggesting it as a potential hormonal therapeutic target.

This study identifies the SPP1-TWIST1-SPON2 signaling axis as a driver of colorectal peritoneal metastasis through cancer-associated fibroblast signaling.

This study investigates how METTL3 regulates RNGTT expression and activity, finding that METTL3 knockdown destabilizes RNGTT mRNA and reduces protein expression, with downstream effects on ribosomal protein capping and mTOR pathway disruption.

This study shows KDM2B promotes ribosome biogenesis by enhancing transcription of ribosome-related genes and affects mRNA translation unequally based on mRNA features.

PHENSIM simulates cell phenotype changes due to biomolecule activation/inhibition using signaling pathways, showing high prediction accuracy through benchmarking.