P. Prakrithi

This paper identifies 116 risk loci for melanoma through GWAS, links susceptibility to immunity and Wnt signaling, and develops a PRS improving risk prediction.

This study shows that myeloid HDAC7 promotes liver inflammation and glucose dysregulation in obesity, using mouse models and human data.

The paper identifies 354,937 novel lncRNAs across 13 cancer types using single-cell and spatial transcriptomics, revealing their cell-type specificity, spatial distribution, and potential functional roles.

The paper integrates 12 spatial and single-cell technologies to analyze cellular interactions and signatures in three skin cancers, identifying key therapeutic targets and genetic associations.

The paper identifies spurious off-target signals from lncRNAs in 10X Visium FFPE spatial transcriptomics data and recommends excluding affected genes.

The paper computes polygenic risk scores for COVID-19 severity in Indian sub-populations using GWAS summary statistics and finds a positive correlation between genetic risk scores and mortality.