Human Medial Ganglionic Eminence Organoids Robustly Generate Parvalbumin Interneurons and Fast-Spiking Neurons and Reveal Migratory Deficits in SLC6A1 Deficient Interneurons
Maria Celeste Varela, Miranda Walker, Jeyoon Bok, Emmanuel L. Crespo, Tyler Thenstedt, Leah Goldstein, Andrew M. Tidball, Yukun Yuan, Lori L. Isom, Jianping Fu, Michael D. Uhler, Jack M. Parent
This paper develops a method to generate MGE organoids from hPSCs that robustly produce PV-expressing interneurons and reveals migration deficits in SLC6A1-deficient interneurons.
bioRxiv · Jul 1, 2025 · PreprintNeuroscience