Yukun Yuan

This paper develops a method to generate MGE organoids from hPSCs that robustly produce PV-expressing interneurons and reveals migration deficits in SLC6A1-deficient interneurons.

This paper demonstrates that vitrification can effectively cryopreserve human cortical organoids, maintaining their structure, cell type composition, and function.

This study investigates the effects of monoallelic Gnao1 loss in mice, finding reduced inhibitory synaptic input to Purkinje cells through electrophysiological analysis.

This study uses patient-derived iPSC neurons to show variant-specific changes in sodium currents in SCN8A-EIEE13, identifying altered persistent and resurgent INa and potential therapeutic responses.

This study shows that ankyrin-G regulates forebrain connectivity and network synchronization through its interaction with GABARAP, and identifies a variant linked to bipolar disorder.