Neural Progenitors as a Novel Pathogenic Mechanism in Microcephaly
Rami Yair Tshuva, Jeyoon Bok, Mio Nonaka, Xufeng Xue, Bidisha Bhattacharya, Aditya Kshirsagar, Tsviya Olender, Miri Danan-Gotthold, Tamar Sapir, Jianping Fu, Orly Reiner
This study shows that NDE1 loss disrupts neural progenitor identity and forebrain patterning, leading to microcephaly through altered ERK signaling and regional identity shifts.
bioRxiv · Aug 12, 2025 · PreprintDevelopmental Biology