Leda Lignos

The selective amyloid-driven failure of cholinergic medial septal neurons in aging mice perturbs REM sleep, cognition and emotion, and broadcasts amyloid to other brain regions

This study shows that amyloid accumulation in medial septal cholinergic neurons of aging mice leads to REM sleep loss, cognitive and emotional deficits, and amyloid spread to other brain regions.

Nitric oxide synthase neurons in the preoptic hypothalamus are sleep-active and contribute to regulating NREM and REM sleep and lowering body temperature.

The paper identifies NOS1 neurons in the preoptic hypothalamus as sleep-active and shows they regulate NREM and REM sleep and body temperature.