Edward C. Harding

This study maps region-specific histopathological features of scrapie-induced neurodegeneration in mouse brain regions at early and late disease stages, identifying key markers and region-specific mechanisms.

The paper uses a mouse prion model and machine learning to identify neuroprotective effects of pioglitazone in neurodegenerative disease.

The paper identifies a short peptide sequence that efficiently targets transmembrane proteins to primary cilia across cell types and develops an image analysis pipeline for automated cilia measurement.

This paper identifies a REM-active basal ganglia circuit in mice that regulates REM sleep and anxiety by showing its role in sleep duration and behavioral responses to aversive stimuli.

This study shows metformin can slow neurodegeneration features in mice, even in metabolically healthy individuals, by acting directly in the brain.

The paper identifies NOS1 neurons in the preoptic hypothalamus as sleep-active and shows they regulate NREM and REM sleep and body temperature.

This study shows that dysfunction of VTA GABA neurons leads to mania-like behaviors, including increased wakefulness and reduced sleep, which can be reversed by valproate.

This study shows that galanin neurons in the hypothalamus regulate sleep homeostasis, body temperature, and the effects of dexmedetomidine.